Do I have to have CPRS running to use Brillians?

No. Brillians is NOT dependent on CPRS in any way. There have been many instances where CPRS was down, but the users could continue providing patient care using Brillians.

However, Brillians depends on the VistA system to get the clinical data. If the network is down, or the VistA system is down, then neither CPRS nor Brillians will work.